Cocaine-Induced Hormonal and Behavioral Changes
نویسندگان
چکیده
منابع مشابه
Behavioral changes induced by cocaine in mice are modified by a hyperlipidic diet or recombinant leptin.
The objective of the present study was to determine if the acute behavioral effects of cocaine acutely administered intraperitoneally (ip) at doses of 5, 10 and 20 mg/kg on white male CF1 mice, 90 days of age, would be influenced by leptin acutely administered ip (at doses of 5, 10 and 20 microg/kg) or by endogenous leptin production enhanced by a high-fat diet. The acute behavioral effects of ...
متن کاملBehavioral changes induced by cocaine in mice are modified by a hyperlipidic diet or recombinant leptin
The objective of the present study was to determine if the acute behavioral effects of cocaine acutely administered intraperitoneally (ip) at doses of 5, 10 and 20 mg/kg on white male CF1 mice, 90 days of age, would be influenced by leptin acutely administered ip (at doses of 5, 10 and 20 μg/kg) or by endogenous leptin production enhanced by a high-fat diet. The acute behavioral effects of coca...
متن کاملMicroglial TNF-α Suppresses Cocaine-Induced Plasticity and Behavioral Sensitization
Repeated administration of cocaine results in the development of behavioral sensitization, accompanied by a decrease in excitatory synaptic strength in the nucleus accumbens (NAc) through an unknown mechanism. Furthermore, glial cells in the NAc are activated by drugs of abuse, but the contribution of glia to the development of addictive behaviors is unknown. Tumor necrosis factor alpha (TNF-α)...
متن کاملCocaine-induced pulmonary changes: HRCT findings *
OBJECTIVE To evaluate HRCT scans of the chest in 22 patients with cocaine-induced pulmonary disease. METHODS We included patients between 19 and 52 years of age. The HRCT scans were evaluated by two radiologists independently, discordant results being resolved by consensus. The inclusion criterion was an HRCT scan showing abnormalities that were temporally related to cocaine use, with no othe...
متن کاملPreadolescent drd1-EGFP mice exhibit cocaine-induced behavioral sensitization.
In adult mice, repeated cocaine administration induces behavioral sensitization measured as increased horizontal locomotor activity. Cocaine-induced locomotor sensitization has been well characterized in adult mice. In adult animals, the D1 dopamine receptor is important for mediating effects of cocaine. The effect of cocaine on D1 receptor expression and function in preadolescent animals is le...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Pediatric Neurology Briefs
سال: 1996
ISSN: 2166-6482,1043-3155
DOI: 10.15844/pedneurbriefs-10-6-3